Study on crystallization separation of ursolic acid and oleanolic acid in ionic liquid

被引：0
|
作者：
Gao Y. [1 ]
Cao Y. [1 ]
Fan J. [1 ]
机构：
[1] School of Resource, Environmental and Chemical Engineering, Nanchang University, Nanchang, 330031, Jiangxi
来源：
Huagong Xuebao/CIESC Journal | 2020年 / 71卷 / 08期
关键词：
Crystallization separation; Ionic liquid; Oleanolic acid; Solubility; Ursolic acid;
D O I：
10.11949/0438-1157.20200003
中图分类号：
学科分类号：
摘要：
To expand the scope of crystallization solvent and improve the performance of crystallization separation of ursolic acid and oleanolic acid, ionic liquids were introduced as the crystallization solvent. The solubility data of ursolic acid and oleanolic acid in six ionic liquids + ethanol mixed solutions were measured. Then the 1-octyl-3-methylimidazole hexafluorophosphate + ethanol mixed solution was selected as the solvent for crystallization separation of ursolic acid and oleanolic acid, and the crystallization process was optimized by single factor experiments. The best process conditions are as follows: mass fraction of 1-octyl-3-methylimidazole hexafluorophosphat 5%, mass ratio of ursolic acid to oleanolic acid 1.5:1, crystallization temperature 30℃, crystallization time 14 h. In this case, the mass fraction of oleanolic acid in the crystals can reach about 85%. © 2020, Chemical Industry Press Co., Ltd. All right reserved.
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页码：3633 / 3643
页数：10
相关论文
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