Fuzhuan Brick Tea Prevents Obesity and Hypercholesterolemia by Regulating the Intestinal Flora and Bile Acid Metabolism

被引：0
|
作者：
Li X. [1 ,2 ]
Ouyang J. [1 ,2 ]
Tang J. [1 ,2 ]
Zhou F. [1 ,2 ]
Huang J. [1 ,2 ,3 ]
Liu Z. [1 ,2 ,3 ]
机构：
[1] Key Lab of Tea Science, Ministry of Education, Hunan Agricultural University, Changsha
[2] National Research Center of Engineering Technology for Utilization Ingredients from Botanicals, Hunan Agricultural University, Changsha
[3] Co-innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Changsha
来源：
Shipin Kexue/Food Science | 2022年 / 43卷 / 09期
关键词：
Bile acid metabolism; Fuzhuan brick tea; Gut microbiota; Obesity prevention;
D O I：
10.7506/spkx1002-6630-20201028-284
中图分类号：
学科分类号：
摘要：
The purpose of this study is to explore the mechanism of action of Fuzhuan brick tea water extract (FTE) in preventing obesity and hypercholesterolemia. Specific pathogen-free Sprague Dawley (SPF SD) rats were selected and divided equally into six groups: normal diet, high-fat diet, positive control (Xuezhikang, a hypolipidemic agent), and low-, medium- and high-dose FTE intervention. A comparative analysis was performed to evaluate the effect of Fuzhuan brick tea in preventing obese dyslipidemia. The results showed that FTE affected the intestinal and hepatic bile acid (BA) metabolism cycle by regulating the structure and function of the intestinal microbiota, enhanced antioxidant capacity and systemic lipid consumption in rats, had a significant protective effect on the structure and function of the liver and intestines, improved the lipid profile and inflammatory response, and inhibited excessive body mass gain induced by a high-fat diet in rats.Collectively, we concluded that FTE has a significant preventive effect on nutritional obesity and hypercholesterolemia, and it is advantageous over Xuezhikang in preventing body mass gain and lipid accumulation, increasing lipid consumption, inhibiting liver functional enzymes and regulating bile acid metabolism. © 2022, China Food Publishing Company. All right reserved.
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页码：136 / 149
页数：13
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