New non-local mean methods for MRI denoising based on global self-similarity between values

Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique that provides high-resolution 3D images and valuable insights into human tissue conditions. Even at present, the refinement of denoising methods for MRI remains a crucial concern for improving the quality of the images. This study aims to improve the prefiltered rotationally invariant non-local principal component analysis (PRI-NL-PCA) algorithm. We relaxed the original restrictions using particle swarm optimization to determine optimal parameters for the PCA part of the original algorithm. In addition, we adjusted the prefiltered rotationally invariant non-local mean (PRI-NLM) part by traversing the signal intensities of voxels instead of their spatial positions to reduce duplicate calculations and expand the search volume to the whole image when estimating voxels’ signal intensities. The new method demonstrated superior denoising performance compared to the original approach. Moreover, in most cases, the new algorithm ran faster. Furthermore, our proposed method can also be applied to process Gaussian noise in natural images and has the potential to enhance other NLM-based denoising algorithms. © 2024