A Review of the Mechanism of Probiotics Controlling Obesity through Intestinal Flora

被引：0
|
作者：
Huang Y. [1 ,2 ]
Liang Y. [1 ,2 ]
Wu J. [1 ,2 ]
Zeng X. [1 ,2 ]
Zeng Q. [1 ,2 ]
Cao S. [1 ,2 ]
Liao L. [1 ,2 ]
Wang L. [1 ,2 ]
机构：
[1] School of Food Science and Engineering, Foshan University of Science and Technology, Foshan
[2] Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University of Science and Technology, Foshan
来源：
Science and Technology of Food Industry | 2023年 / 44卷 / 08期
关键词：
fat; intestinal flora; mechanism; obesity; probiotics;
D O I：
10.13386/j.issn1002-0306.2022080280
中图分类号：
学科分类号：
摘要：
Obesity is an abnormal accumulation of fat caused by metabolic dysfunction, which can lead to various metabolic syndromes such as atherosclerosis, insulin resistance, and dyslipidemia. Obesity threatens modern society's health and economic development and has always been a research focus. Currently, some mechanisms of intestinal flora inhibiting obesity have been reported. However, due to the complexities of intestinal microbial composition, it is unclear which microbial community is directly related to obesity. The structural changes of intestinal flora in obese patients are used as a starting point in this review to elaborate further on the close relationship between the physiological function of intestinal flora and the pathogenesis of obesity. Based on the summary of relevant research progress at home and abroad, it is concluded that probiotics can directly affect the level of inflammatory cytokines and metabolites in the intestine of obese patients, or regulate the balance of intestinal flora to reshape the metabolism of obese hosts. Thus, probiotics and prebiotics would become new avenues for preventing and treating obesity. © 2023 Editorial Department of Science and Technology of Food Science.
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页码：1 / 8
页数：7
相关论文
共 70 条
  • [1] DETTONI R, BAHAMONDES C, YEVENES C, Et al., The effect of obesity on chronic diseases in USA: A flexible copula approach[J], Scientific Reports, 13, 1, (2023)
  • [2] LAUDISIO D, MUSCOGIURI G, BARREA L, Et al., Obesity and breast cancer in premenopausal women: Current evidence and future perspectives[J], European Journal of Obstetrics and Gynecology and Reproductive Biology, 230, pp. 217-221, (2018)
  • [3] GAO P, ZHANG X G, LIU X L., Research progress in evaluation of intestinal mucosal barrier function[J], Journal of Developmental Medicine Electronics, 7, 1, (2019)
  • [4] HE X, JI G, JIA W, Et al., Gut microbiota and nonalcoholic fatty liver disease: Insights on mechanism and application of metabolomics, International Journal of Molecular Sciences, 17, 3, (2016)
  • [5] WANG X, WANG L, WANG Q Y, Et al., Study on the growth and metabolism of probiotics by prebiotics[J], Food Safety Guide, 2022, 7
  • [6] CRISTOFORI F, DARGENIO V N, DARGENIO C, Et al., Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: A door to the body[J], Frontiers in Immunology, 12, (2021)
  • [7] FANG F C, VAZQUEZ-TORRES A., Reactive nitrogen species in host-bacterial interactions[J], Current Opinion in Immunology, 60, (2019)
  • [8] ZHOU B, YUAN Y, ZHANG S, Et al., Intestinal flora and disease mutually shape the regional immune system in the intestinal tract[J], Frontiers in Immunology, 11, (2020)
  • [9] CHEN Y Y, WANG R, ZHANG J H, Et al., Research progress on the effect of intestinal flora on drug metabolism[J], China Pharmacology Bulletin, 35, 2, (2019)
  • [10] MOBEEN F, SHARMA V, TULIKA P., Enterotype variations of the healthy human gut microbiome in different geographical regions[J], Bioinformation, 14, 9, (2018)
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