Recent advances in fluorinated products biosynthesis

被引：1
|
作者：
Shi, Sanyuan [1 ,2 ]
Tian, Jingrui [1 ,2 ]
Luo, Yunzi [1 ,2 ,3 ]
机构：
[1] Tianjin Univ, Frontiers Sci Ctr Synthet Biol, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China
[3] Tianjin Univ, Georgia Tech Shenzhen Inst, Tangxing Rd 133, Shenzhen 518071, Peoples R China
来源：
BIORESOURCE TECHNOLOGY REPORTS | 2022年 / 20卷
基金：
中国国家自然科学基金;
关键词：
Fluorinated natural products; Fluorinated polyketides; Fluorinases; Nucleocidin; Synthetic biology; FLUOROMETABOLITE BIOSYNTHESIS; STREPTOMYCES-CATTLEYA; POLYKETIDE SYNTHASE; NATURAL-PRODUCTS; NUCLEOCIDIN; THIOESTERASE; 4-FLUOROTHREONINE; FLUOROACETATE; METABOLISM; DISCOVERY;
D O I：
10.1016/j.biteb.2022.101288
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The introduction of fluorine to the drug molecules endows the compounds with better metabolic stability and bioavailability. However, naturally occurring fluorides are rare and there are challenges in identification of natural fluorination pathways and their corresponding fluorinases. Synthetic biology strategies have been applied to construct artificial fluorination pathways via incorporation of fluorine into the polyketide backbone, which provides new routes to synthesize fluorides with complex structures. This review summarizes the latest research progresses in mining natural fluorination pathways and the engineering of artificial fluorination pathways.
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页数：8
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