Protective Effect and Mechanism of Inonotus obliquus Polysaccharide on Blood Lipids and Liver in Hyperlipidemia Rats Induced by High-Fat Diet

被引：0
|
作者：
Cui J. [1 ]
Wang S. [1 ]
Liu C. [1 ]
Yu T. [1 ]
Chen X. [1 ]
机构：
[1] College of Food Science and Engineering, Jilin Agricultural University, Changchun
来源：
Shipin Kexue/Food Science | 2020年 / 41卷 / 19期
关键词：
Hypolipidemic; Inonotus obliquus; Lipid peroxidation; Liver injury; Polysaccharide;
D O I：
10.7506/spkx1002-6630-20191015-147
中图分类号：
学科分类号：
摘要：
Objective: To investigate the intervention effect of Inonotus obliquus polysaccharide (IOP) on liver disease in hyperlipidemic rats by measuring serum lipid content, antioxidant defense indices, liver damage and fatty acid synthase activity. Methods: Forty male Sprague-Dawley (SD) rats were randomly divided into normal control, hyperlipidemia model and low-, medium- and high-dose IOP groups. Commercial kits were employed to determine the following blood lipid parameters: total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL);antioxidant indices: superoxide diamutase (SOD), malondialdehyde (MDA) and glutathion peroxide (GSH-Px); liver injury indices: alanine aminotransferase (ALT) and aspartate aminotransferase (AST); and fatty acid synthetase (FAS) and human hydroxymethylglutaryl CoA reductase (HMGCR). Results: Compared with the high-fat group, high-dose (200 mg/kg mb)of Inonotus obliquus polysaccharide has a significant effect on reducing blood lipid levels in rats and protecting liver from damage. And the dose group TC, TG, LDL decreased significantly, HDL increased significantly, MDA content decreased, SOD, GSH-Px activity increased, FAS and HMGCR activity decreased significantly. Conclusion: Polysaccharide from Inonotus obliquus can protect against lipid disorders, liver damage in rats with hyperlipidemia caused by high-fat diet, may be related to its antioxidant effect. © 2020, China Food Publishing Company. All right reserved.
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页码：185 / 190
页数：5
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