Serum levels of B-cell activating factor are associated with a reduced risk of chronic lymphocytic leukemia

被引：0
|
作者：
Frost, Eleanor [1 ]
Hofmann, Jonathan N. [2 ]
Huang, Wen-Yi [2 ]
Frazer-Abel, Ashley A. [3 ]
Deane, Kevin D. [3 ]
Berndt, Sonja I. [2 ]
机构：
[1] Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA USA
[2] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
[3] Univ Colorado, Dept Med, Anschutz Med Campus, Denver, CO USA
来源：
BLOOD CANCER JOURNAL | 2024年 / 14卷 / 01期
关键词：
BAFF; SURVIVAL; CANCER;
D O I：
10.1038/s41408-024-01106-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ImpactImmune dysregulation is thought to contribute to chronic lymphocytic leukemia (CLL) risk, but biological mechanisms are unclear. We discovered that increased serum levels of B-cell activating factor (BAFF), an important regulator of B-cell maturation, were associated with a decreased risk of CLL, even >10years after blood draw. Our findings suggest that BAFF could be a useful biomarker to assess risk among individuals at high risk, such as those with monoclonal b-cell lymphocytosis.
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页数：4
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