Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology

BackgroundDigital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer's disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (A beta) pathology of speech acoustics measured over multiple assessments in a remote setting.MethodsFifty cognitively unimpaired adults (Age 68 +/- 6.2 years, 58% female, 46% A beta-positive) completed remote, tablet-based speech assessments (i.e., picture description, journal-prompt storytelling, verbal fluency tasks) for five days. The testing paradigm was repeated after 2-3 weeks. Acoustic speech features were automatically extracted from the voice recordings, and mean scores were calculated over the 5-day period. We assessed feasibility by adherence rates and usability ratings on the System Usability Scale (SUS) questionnaire. Test-retest reliability was examined with intraclass correlation coefficients (ICCs). We investigated the associations between acoustic features and A beta-pathology, using linear regression models, adjusted for age, sex and education.ResultsThe speech assessment was feasible, indicated by 91.6% adherence and usability scores of 86.0 +/- 9.9. High reliability (ICC >= 0.75) was found across averaged speech samples. A beta-positive individuals displayed a higher pause-to-word ratio in picture description (B = -0.05, p = 0.040) and journal-prompt storytelling (B = -0.07, p = 0.032) than A beta-negative individuals, although this effect lost significance after correction for multiple testing.ConclusionOur findings support the feasibility and reliability of multi-day remote assessment of speech acoustics in cognitively unimpaired individuals with and without A beta-pathology, which lays the foundation for the use of speech biomarkers in the context of early AD.