Effect of Anthocyanin Extract of Lycium ruthenicum Murr. on Rats with Acute Gouty Arthritis

被引：0

作者：

Yan S. ^{[1
,2
]}

Wang S. ^{[1
]}

Chen T. ^{[1
,2
]}

Shen C. ^{[1
]}

Zhao J. ^{[3
]}

Ding Y. ^{[3
]}

Kong L. ^{[3
]}

Yang L. ^{[1
]}

Li Y. ^{[1
]}

机构：

[1] Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining

[2] Savaid Medical School, University of Chinese Academy of Sciences, Beijing

[3] Qinghai Jinmaiqi Biotechnology Co LTD, Xining

来源：

Journal of Food Science and Technology (China) | 2022年 / 40卷 / 03期

关键词：

Acute gouty arthritis; Ankle joint swelling; Anthocyanin extract of Lycium ruthenicum Murr; Claudication gait; Serum uric acid;

D O I：

10.12301/spxb202100218

中图分类号：

学科分类号：

摘要：

To investigate the prevention effect of anthocyanin extract of Lycium ruthenicum Murr. (AEL) on rats with acute gouty arthritis (AGA), 60 male SD rats were randomly divided into 5 groups, including normal control group, model control group, positive control group, AEL high dose group (238.0 mg/kg) and AEL low dose group (59.5 mg/kg). There were 12 rats in each group. Animals in each group were divided into 2 batches with 6 rats in each batch. After gavage for 2 weeks in the first batch of animals and 4 weeks in the second batch of animals, the rat model of AGA induced by injecting 0.2 mL of 50 mg/mL microcrystalline sodium urate into the right ankle of rats, and the effect of AEL on ankle joint swelling and claudication gait of AGA rats were evaluated. After continued gavage for 5 weeks, hyperuricemia model was induced by feeding 2.5% potassium oxazinate. The serum uric acid level of rats was measured after modeling at 2 h and 3 h. It was found that compared with the model control group, high dose of AEL after gavage for 2 weeks could significantly alleviate the ankle joint swelling and improve the claudication gait of rats at 6 h after modeling. After gavage for 4 weeks, both high and low doses of AEL could significantly alleviate the ankle joint swelling at 6 h and 24 h and improve the claudication gait of rats at 6 h after modeling, and high doses of AEL could also significantly improve the claudication gait at 24 h after modeling. After 5 weeks of gavage, both high and low doses of AEL could significantly inhibit the increment of serum uric acid induced by potassium oxazinate. The results showed that AEL could significantly improve AGA in rats through anti-inflammatory effect and reducing uric acid. © 2022, Editorial Department of Journal of Food Science and Technology. All right reserved.

引用

页码：105 / 111

页数：6

共 22 条

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