High-resolution brain tractography from X-ray phase-contrast images

被引:0
|
作者
Gobe, Joshua [1 ]
Rositi, Hugo [2 ]
Vacavant, Antoine [3 ]
Riviere, Margaux [1 ]
Po, Chrystelle [4 ]
Chourrout, Matthieu [1 ]
Chauveau, Fabien [1 ]
机构
[1] Univ Claude Bernard Lyon 1, Lyon Neurosci Res Ctr, CNRS, INSERM, F-69500 Bron, France
[2] Univ Lorraine, LORIA, CNRS, F-54000 Nancy, France
[3] Univ Clermont Auvergne, Inst Pascal, Clermont Auvergne INP, CNRS, F-63000 Clermont Ferrand, France
[4] Univ Strasbourg, CNRS, ICube, UMR 7357, F-67000 Strasbourg, France
来源
EUROPEAN PHYSICAL JOURNAL PLUS | 2024年 / 139卷 / 07期
关键词
D O I
10.1140/epjp/s13360-024-05357-y
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
X-ray phase contrast tomography (XPCT) can produce high contrast isotropic images of biological samples in only a few minutes thanks to the unique properties of the synchrotron X-ray beam. XPCT of brain tissue provides an exquisite contrast of white matter, which could be exploited for 3D directional analysis. In this article, we present the first XPCT-based pipeline to perform white matter tractography on rodent brains. We observed the disorganization of white matter in the vicinity of focal demyelinating lesions in the corpus callosum. The ability to obtain an isotropic, high-resolution tractogram is an important landmark which could drive further interest of the neuroscience community toward XPCT.
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页数:9
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