Regioselective N1-methylation of 1H-tetrazoles with methyl 2,2,2-trichloroacetimidate

被引：0

作者：

Baddam, Sudhakar Reddy ^{[1
]}

Kalagara, Sudhakar ^{[2
]}

Ganta, Srinivas ^{[3
]}

Ponnuru, Venkata Suresh ^{[4
]}

Vudari, Balaraju ^{[5
]}

Nalla, Seshadri ^{[6
]}

机构：

[1] Univ Massachusetts, Chan Med Sch, RNA Therapeut Inst, Worcester, MA 01655 USA

[2] Univ Texas El Paso, Dept Chem & Biochem, El Paso, TX USA

[3] ScieGen Pharmaceut Inc, Hauppauge, NY USA

[4] Texas Tech Univ, Hlth Sci Pediat Canc Res Ctr, Lubbock, TX USA

[5] Sreenidhi Inst Sci & Technol, Hyderabad, Telangana, India

[6] Cambrex Pharmaceut Co, Charles City, IA USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2024年 / 61卷 / 07期

关键词：

TETRAZOLES; FRAMEWORKS;

D O I：

10.1002/jhet.4824

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, mild, and regioselective synthesis of substituted 1-methyl-1H-tetrazole using methyl 2,2,2-trichloroacetimidate is described. The substrate scope of the methodology has been established with wide variety of tetrazoles. N1-Methylated tetrazoles were synthesized with high yields (85%-97%).

引用

页码：1066 / 1069

页数：4

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