Two New Antibacterial Isoindolin-1-Ones from Sun-Cured Tobacco and Their Potential Application in Antiseptic Cigarette Tipping Paper

Two new isoindolin-1-ones (1 and 2), were isolated from the stems of Nicotiana tabacum (a cultivar of sun-cured tobacco with high resistance to black shank diseases, which originated from Huize local sun-cured tobacco by ethyl methanesulfonate mutagenesis). Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Interestingly, both compounds showed high antibacterial activity with bacteriostatic diameter within the range 18.2 +/- 1.4-25.8 +/- 2.2 mm against five pathogenic strains, and they have the potential values for use as an antiseptic agent for Heat Not Burning cigarette-tipping paper.