Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study

被引：0
|
作者：
Yang, Yuanfang [1 ]
Xue, Minsong [1 ]
Hao, Jiangdong [1 ]
Lin, Zhenghua [4 ,7 ]
Xi, Xiaoyun [1 ]
Wu, Haoran [4 ]
Wen, Longbo [4 ]
Xu, Qinglin [4 ]
Luo, Zhiwei [4 ]
Ran, Guangyao [1 ]
Artal, Pablo [1 ,7 ]
Lan, Weizhong [1 ,4 ]
Li, Xiaoning [2 ,3 ,4 ,5 ,6 ]
Yang, Zhikuan [1 ,4 ,5 ,6 ]
机构：
[1] Cent South Univ, Aier Sch Ophthalmol, Changsha 410015, Peoples R China
[2] Changsha Aier Eye Hosp, Changsha 410015, Peoples R China
[3] Hubei Univ Sci & Technol, Xianning Med Coll, Sch Stomatol & Ophthalmol, Xianning 437000, Peoples R China
[4] Aier Inst Optometry & Vis Sci, Changsha 410015, Peoples R China
[5] Hunan Prov Optometry Engn & Technol Res Ctr, Changsha 410015, Peoples R China
[6] Hunan Prov Int Cooperat Base Optometry Sci & Techn, Changsha 410015, Peoples R China
[7] Univ Murcia, Lab Opt, Campus Espinardo, Murcia 30100, Spain
来源：
EYE AND VISION | 2024年 / 11卷 / 01期
关键词：
0.05% atropine eyedrops; Myopia control; Peripheral defocus; Medication compliance; REFRACTIVE ERROR; EYE GROWTH; SHAPE; SCHOOLCHILDREN; EMMETROPIA; EFFICACY; CHILDREN; VISION; TRIAL;
D O I：
10.1186/s40662-024-00395-0
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
BackgroundAtropine, specifically 0.05% eyedrops, has proven effective in slowing myopia progression. This study aims to investigate peripheral refraction (PR) characteristics in myopic children treated with 0.05% atropine eyedrops at different frequencies. MethodsOne hundred thirty-eight myopic children completed this one-year prospective study, randomly assigned to once daily (7/7), twice per week (2/7), or once per week (1/7) groups. Spherical equivalent (SE) and axial length (AL) were measured. PR was assessed using a custom-made Hartmann-Shack wavefront peripheral sensor, covering a visual field of horizontal 60 degrees and vertical 36 degrees. Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements. ResultsAfter one year, SE increased more significantly in the 1/7 group compared to the 7/7 group (P < 0.001) and 2/7 group (P = 0.004); AL elongation was also greater in the 1/7 group compared to the 7/7 group (P < 0.001). In comparison with higher frequency groups, 1/7 group exhibited more myopic PR in the fovea and its vertical superior, inferior, and nasal retina; and less myopic RPR in the periphery retina after one-year (P < 0.05). Additionally, RPR in the 7/7 group demonstrated myopic shift across the entire retina, the 2/7 group in temporal and inferior retina, while the 1/7 group showed a hyperopic shift in the superior retina (P < 0.05). Moreover, myopic shift of RPR in the temporal retina is related to less myopia progression, notably in the 7/7 group (P < 0.05). ConclusionsAtropine inhibits myopia progression in a frequency-dependent manner. The once-daily group showed the slowest myopia progression but exhibited more myopic shifts in RPR. Additionally, RPR in the temporal retina was related to myopia progression in all groups. Trial registrationChinese Clinical Trial Registry, ChiCTR2100043506. Registered 21 February 2021, https://www.chictr.org.cn/showproj.html?proj=122214
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页数：11
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