Regulatory role of CD39 and CD73 in tumor immunity

被引：2
|
作者：
Kaplinsky, Nicole [1 ]
Williams, Kada [1 ]
Watkins, Dean [1 ]
Adams, Molly [1 ]
Stanbery, Laura [2 ]
Nemunaitis, John [2 ]
机构：
[1] Univ Toledo, Coll Med, Toledo, OH 43614 USA
[2] Gradalis Inc, Dallas, TX 75006 USA
来源：
FUTURE ONCOLOGY | 2024年 / 20卷 / 19期
关键词：
adenosine pathway; antigen; CD39; CD73; ENTPD1; immunotherapy; tumor microenvironment; T-CELLS; EXTRACELLULAR ADENOSINE; ATP; DISEASE; GROWTH; CANCER; INHIBITION; THERAPY;
D O I：
10.2217/fon-2023-0871
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CD39 is the rate-limiting enzyme for the molecular signal cascade leading to the generation of ADP and adenosine monophosphate (AMP). In conjunction with CD73, CD39 converts adenosine triphosphate (ATP) to ADP and AMP, which leads to the accumulation of immunosuppressive adenosine in the tumor microenvironment. This review focuses on the role of CD39 and CD73 in immune response and malignant progression, including the expression of CD39 within the tumor microenvironment and its relationship to immune effector cells, and its role in antigen presentation. The role of CD39- and CD73-targeting therapeutics and cancer-directed clinical trials investigating CD39 modulation are also explored.
引用
收藏
页码：1367 / 1380
页数：14
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