Amino-acid PET as a prognostic tool after post Stupp protocol temozolomide therapy in high-grade glioma patients

被引:2
|
作者
Zinsz, Adeline [1 ]
Ahrari, Shamimeh [2 ]
Becker, Jason [3 ]
Mortada, Ali [1 ]
Roch, Veronique [1 ]
Doriat, Louis [1 ]
Santi, Matthieu [1 ]
Blonski, Marie [3 ]
Taillandier, Luc [3 ]
Zaragori, Timothee [1 ]
Verger, Antoine [1 ,2 ,4 ]
机构
[1] Univ Lorraine, Dept Nucl Med & Nancyclotep Imaging Platform, CHRU Nancy, F-54000 Nancy, France
[2] Univ Lorraine, IADI, INSERM, U1254, F-54000 Nancy, France
[3] Univ Lorraine, Dept Neurooncol, CHRU Nancy, F-54000 Nancy, France
[4] CHRU Nancy, Nucl Med Dept, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France
关键词
Glioma; PET; Temozolomide; Survivals; Stupp; Treatment monitoring;
D O I
10.1007/s11060-024-04722-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PurposeThis study aimed to evaluate the prognostic performance of amino-acid PET in high-grade gliomas (HGG) patients at the time of temozolomide (TMZ) treatment discontinuation, after the Stupp protocol.MethodsThe analysis included consecutive HGG patients with dynamic [18F]FDOPA PET imaging within 3 months of the end of TMZ therapy, post-Stupp protocol. Static and dynamic PET parameters, responses to RANO criteria for MRI and clinical and histo-molecular factors were correlated to progression-free (PFS).ResultsThirty-two patients (59.4 [54.0;67.6] years old, 13 (41%) women) were included. Static PET parameters peak tumor-to-background ratio and metabolic tumor volume (respective thresholds of 1.9 and 1.5 mL) showed the best 84% accuracies for predicting PFS at 6 months (p = 0.02). These static PET parameters were also independent predictor of PFS in multivariate analysis (p <= 0.05).ConclusionIn HGG patients having undergone a Stupp protocol, the absence of significant PET uptake after TMZ constitutes a favorable prognostic factor.
引用
收藏
页码:241 / 245
页数:5
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