The Anti-obesity Effect of Monascus-fermented Radix Puerariae Extract on High-fat Induced Obese Mice

被引：0
|
作者：
He D. [1 ]
Zhu X. [1 ]
Chen L. [1 ]
Liu Z. [1 ]
Ni L. [1 ]
机构：
[1] Institute of Food Science and Technology, Fuzhou University, Fujian Center of Excellence for Food Biotechnology, Fuzhou
来源：
Journal of Chinese Institute of Food Science and Technology | 2019年 / 19卷 / 11期
关键词：
Lipid-lowering; Monascus; Monascus-fermented radix puerariae extracts; Obesity;
D O I：
10.16429/j.1009-7848.2019.11.003
中图分类号：
学科分类号：
摘要：
Objective: To explore the anti-obesity effect of Monascus-fermented Radix Puerariae extracts(MRPE) on high-fat induced obese C57BL/6J mice. Method. Thirty-two C57BL/6J mice were fed with high-fat diet to induce obesity. Then, the 32 obese mice were irrigated with distilled water (HF group, n = 8), Monacolin K (MK group, n = 8), normal dose of MRPE (MRPE-C group, n = 8), and high dose of MRPE(MRPE-H group, n = 8), respectively. After 4 weeks, the body weights, body lengths, abdominal fat, body-fat ratio and Lee's index were recorded. Moreover, serum total cholesterol, triglyceride, HDL, LDL and serum lipopolysaccharide (LBP) were also measured. Results Compared with HF group, the body weight, body-fat ratio, Lee's index, the serum contents of TC, TG and LBP of the mice from both MRPE-C group and MRPE-H group were reduced (P<0.05). The serum HDL-C levels were also increased by MRPE treatment (P<0.05). Moreover, high dose of MRPE treatment could significantly reduce the serum LDL-C level of mice (P<0.05). In general, a dose-dependent anti-obesity effect of MRPE was observed. Compared with MRPE-C group, body-fat ratio and serum LDL-C level of the mice treated with high dose of MRPE were reduced by 20.43% and 8.22%, respectively. In addition, the anti-obesity and lipid profile modification effect of high dose of MRPE was similar to Monacolin K. Conclusion MRPE can alleviate fat accumulation and reduce body weights of high-fat induced obese mice effectively, which indicated the anti-obesity effect of MRPE. © 2019, Editorial Office of Journal of CIFST. All right reserved.
引用
收藏
页码：25 / 30
页数：5
相关论文
共 14 条
  • [1] Hsu W.H., Chen T.H., Lee B.H., Et al., Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice, Food and Chemical Toxicology, 64, pp. 94-103, (2014)
  • [2] Endo A., Monacolin K, a new hypocholesterolemic agent produced by a Monascus species, The Journal of Antibiotics, 32, 8, pp. 852-854, (1979)
  • [3] Lee Y.S., Choi B.K., Lee H.J., Et al., Monascus pilosus - fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice, Asian Pacific Journal of Tropical Medicine, 8, 4, pp. 276-282, (2015)
  • [4] Lee B.H., Hsu W.H., Hsu Y.W., Et al., Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid, Free Radical Biology and Medicine, 60, pp. 7-16, (2013)
  • [5] Liu Z., Wang Z., Lv X., Et al., Comparison study of the volatile profiles and microbial communities of Wuyi Qu and Gutian Qu, two major types of traditional fermentation starters of Hong Qu glutinous rice wine, Food Microbiology, 69, 2, pp. 105-115, (2018)
  • [6] Lee Y.S., Choi B.K., Lee H.J., Et al., Monascus pilosus - fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice, Asian Pacific Journal of Tropical Medicine, 8, 4, pp. 276-282, (2015)
  • [7] Wang W.H., Zhang H., Yu Y.L., Et al., Intervention of xuezhikang on patients of acute coronary syndrome with different levels of blood lipids, Chinese Journal of Integrated Traditional and Western Medicine, 24, 12, pp. 1073-1076, (2004)
  • [8] Hsu W.H., Lee B.H., Chang Y.Y., Et al., A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia, Toxicology and Applied Pharmacology, 272, 3, pp. 842-851, (2013)
  • [9] Feng Y., Shao Y., Chen F., Monascus pigments, Applied Microbiology and Biotechnology, 96, 6, pp. 1421-1440, (2012)
  • [10] Moreno-Navarrete J.M., Escote X., Ortega F., Et al., A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction, Diabetologia, 56, 11, pp. 2524-2537, (2013)
12