Advances in the synthesis of chiral amines by biocatalytic C-N bond formation

被引：0
|
作者：
Cheng Y. [1 ]
Wu J. [1 ]
Liu L. [2 ]
Song W. [1 ]
机构：
[1] School of Pharmaceutical Sciences, Jiangnan University, Wuxi
[2] State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi
来源：
Song, Wei (weisong@jiangnan.edu.cn) | 1600年 / Materials China卷 / 72期
关键词：
Biocatalysis; C-N bond; Catalyst; Enzyme; Hydroamination; Reductive amination; Transamination;
D O I：
10.11949/0438-1157.20201075
中图分类号：
学科分类号：
摘要：
Biocatalytic C-N bond formation is mainly used to synthesize chiral amines, which are widely used in the preparation of foods, fine chemicals and pharmaceutical intermediates. Enzymatic production of chiral amines is characterized by high enantioselectivity, conversion and space-time yield. This review mainly introduces three ways of C-N bond formation, which are reductive amination reaction, hydrogen amination reaction and transamination reaction. The related enzymes were summarized according to different reaction types. © 2021, Editorial Board of CIESC Journal. All right reserved.
引用
收藏
页码：205 / 215
页数：10
相关论文
共 74 条
  • [1] Ghislieri D, Turner N J., Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines, Topics in Catalysis, 57, 5, pp. 284-300, (2014)
  • [2] Grogan G., Synthesis of chiral amines using redox biocatalysis, Current Opinion in Chemical Biology, 43, pp. 15-22, (2018)
  • [3] Hallen A, Cooper A J L, Jamie J F, Et al., Mammalian forebrain ketimine reductase identified as mu-crystallin
  • [4] potential regulation by thyroid hormones, Journal of Neurochemistry, 118, 3, pp. 379-387, (2011)
  • [5] Hallen A, Cooper A J L, Smith J R, Et al., Ketimine reductase/CRYM catalyzes reductive alkylamination of alpha-keto acids, confirming its function as an imine reductase, Amino Acids, 47, 11, pp. 2457-2461, (2015)
  • [6] Hyslop J F, Lovelock S L, Sutton P W, Et al., Biocatalytic synthesis of chiral N-functionalized amino acids, Angewandte Chemie-International Edition, 57, 42, pp. 13821-13824, (2018)
  • [7] Mitsukura K, Kuramoto T, Yoshida T, Et al., A NADPH-dependent (S)-imine reductase (SIR) from Streptomyces sp. GF3546 for asymmetric synthesis of optically active amines: purification, characterization, gene cloning, and expression, Applied Microbiology and Biotechnology, 97, 18, pp. 8079-8086, (2013)
  • [8] Maugeri Z, Rother D., Application of imine reductases (IREDs) in micro-aqueous reaction systems, Advanced Synthesis & Catalysis, 358, 17, pp. 2745-2750, (2016)
  • [9] Wetzl D, Gand M, Ross A, Et al., Asymmetric reductive amination of ketones catalyzed by imine reductases, ChemCatChem, 8, 12, pp. 2023-2026, (2016)
  • [10] Aleku G A, France S P, Man H, Et al., A reductive aminase from Aspergillus oryzae, Nature Chemistry, 9, 10, pp. 961-969, (2017)
12345678