Rapid prototyping of thermoplastic microfluidic devices via SLA 3D printing

被引:0
|
作者
Khoo, Harrison [1 ]
Allen, William Shaen [2 ]
Arroyo-Curras, Netzahualcoyotl [3 ,4 ]
Hur, Soojung Claire [1 ,4 ,5 ]
机构
[1] Johns Hopkins Univ, Dept Mech Engn, 3400 N Charles ST,Latrobe 105, Baltimore, MD 21218 USA
[2] Baltimore Polytech Inst, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA
[5] Johns Hopkins Univ Hosp, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21224 USA
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
FABRICATION; MOLDS; PMMA; COMMERCIALIZATION; CIRCUITS; SURFACE; EPOXY;
D O I
10.1038/s41598-024-68761-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Microfluidic devices have immense potential for widespread community use, but a current bottleneck is the transition from research prototyping into mass production because the gold standard prototyping strategy is too costly and labor intensive when scaling up fabrication throughput. For increased throughput, it is common to mold devices out of thermoplastics due to low per-unit costs at high volumes. However, conventional fabrication methods have high upfront development expenses with slow mold fabrication methods that limit the speed of design evolution for expedited marketability. To overcome this limitation, we propose a rapid prototyping protocol to fabricate thermoplastic devices from a stereolithography (SLA) 3D printed template through intermediate steps akin to those employed in soft lithography. We apply this process towards the design of self-operating capillaric circuits, well suited for deployment as low-cost decentralized assays. Rapid development of these geometry- and material-dependent devices benefits from prototyping with thermoplastics. We validated the constructed capillaric circuits by performing an autonomous, pre-programmed, bead-based immunofluorescent assay for protein quantification. Overall, this prototyping method provides a valuable means for quickly iterating and refining microfluidic devices, paving the way for future scaling of production.
引用
收藏
页数:11
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