Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos

被引：2

作者：

Zhou, Renyi ^{[1
]}

Guo, Jiarong ^{[1
]}

Jin, Zhe ^{[1
]}

机构：

[1] China Med Univ, Hosp 1, Dept Orthoped, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2024年 / 22卷 / 01期

关键词：

Osteoarthritis; Hydrogel; Exosomes; TGFB1; Nrf2; signaling; Cartilage regeneration; DIAGNOSIS; PROMOTE; KNEE;

D O I：

10.1186/s12951-024-02713-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This study investigated the mechanism of the extracellular matrix-mimicking hydrogel-mediated TGFB1/Nrf2 signaling pathway in osteoarthritis using bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos). A GMOCS-Exos hydrogel was synthesized and evaluated for its impact on chondrocyte viability and neutrophil extracellular traps (NETs) formation. In an OA rat model, GMOCS-Exos promoted cartilage regeneration and inhibited NETs formation. Transcriptome sequencing identified TGFB1 as a key gene, with GMOCS-Exos activating Nrf2 signaling through TGFB1. Depletion of TGFB1 hindered the cartilage-protective effect of GMOCS-Exos. This study sheds light on a promising therapeutic strategy for osteoarthritis through GMOCS-Exos-mediated TGFB1/Nrf2 pathway modulation.

引用

页数：24