SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives

被引：2
|
作者：
Lyu, Nana [1 ]
Hassanzadeh-Barforoushi, Amin [1 ]
Rey Gomez, Laura M. [1 ]
Zhang, Wei [1 ]
Wang, Yuling [1 ]
机构：
[1] Macquarie Univ, Sch Nat Sci, Sydney, NSW 2109, Australia
来源：
NANO CONVERGENCE | 2024年 / 11卷 / 01期
基金：
澳大利亚研究理事会;
关键词：
ENHANCED RAMAN-SPECTROSCOPY; HIGHLY SENSITIVE DETECTION; LATERAL FLOW IMMUNOASSAY; TUMOR-CELLS; MULTIPLEX DETECTION; HEPATOCELLULAR-CARCINOMA; RAPID IDENTIFICATION; MICROFLUIDIC CHIP; ANTIGEN; 125; ACCURATE;
D O I：
10.1186/s40580-024-00428-3
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Liquid biopsy has emerged as a promising non-invasive strategy for cancer diagnosis, enabling the detection of various circulating biomarkers, including circulating tumor cells (CTCs), circulating tumor nucleic acids (ctNAs), circulating tumor-derived small extracellular vesicles (sEVs), and circulating proteins. Surface-enhanced Raman scattering (SERS) biosensors have revolutionized liquid biopsy by offering sensitive and specific detection methodologies for these biomarkers. This review comprehensively examines the application of SERS-based biosensors for identification and analysis of various circulating biomarkers including CTCs, ctNAs, sEVs and proteins in liquid biopsy for cancer diagnosis. The discussion encompasses a diverse range of SERS biosensor platforms, including label-free SERS assay, magnetic bead-based SERS assay, microfluidic device-based SERS system, and paper-based SERS assay, each demonstrating unique capabilities in enhancing the sensitivity and specificity for detection of liquid biopsy cancer biomarkers. This review critically assesses the strengths, limitations, and future directions of SERS biosensors in liquid biopsy for cancer diagnosis.
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页数：39
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