Genotypic Profiling, Functional Analysis, Cholesterol-Lowering Ability, and Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity of Probiotic Lactiplantibacillus plantarum K25 via Different Approaches

被引：1

作者：

Aziz, Tariq ^{[1
]}

Hangyu, Hu ^{[1
]}

Naveed, Muhammad ^{[2
]}

Shabbir, Muhammad Aqib ^{[2
,3
]}

Sarwar, Abid ^{[1
]}

Nasbeeb, Jasra ^{[1
]}

Zhennai, Yang ^{[1
]}

Alharbi, Metab ^{[4
]}

机构：

[1] Business Univ Haidian Dist, Engn & Technol Res Ctr Food Addit, Beijing Adv Innovat Ctr Food Nutr & Human Hlth Bei, Key Lab Geriatr Nutr & Hlth,Minist Educ, 11 Fucheng Rd, Beijing 100048, Peoples R China

[2] Lahore Univ Biol & Appl Sci, Fac Pharmaceut Sci, Dept Pharmaceut, Lahore, Pakistan

[3] Univ Cent Punjab, Fac Sci & Technol, Dept Biotechnol, Lahore 54590, Punjab, Pakistan

[4] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, POB 2455, Riyadh 11451, Saudi Arabia

来源：

PROBIOTICS AND ANTIMICROBIAL PROTEINS | 2024年

基金：

中国国家自然科学基金;

关键词：

Probiotic; Lactiplantibacillus; Pan genomics; Comparative genomics; Genotyping; ACID;

D O I：

10.1007/s12602-024-10258-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Due to its alleged health advantages, several uses in biotechnology and food safety, the well-known probiotic strain Lactiplantibacillus plantarum K25 has drawn interest. This in-depth investigation explores the genetic diversity, makeup, and security characteristics of the microbial genome of L. plantarum K25, providing insightful knowledge about its genotypic profile and functional characteristics. Utilizing cutting-edge bioinformatics techniques like comparative genomics, pan-genomics, and genotypic profiling was carried out to reveal the strain's multidimensional potential in various fields. The results not only add to our understanding of the genetic makeup of L. plantarum K25 but also show off its acceptability in various fields, notably in biotechnology and food safety. The explanation of evolutionary links, which highlights L. plantarum K25's aptitude as a probiotic, is one notable finding from this research. Its safety profile, which is emphasized by the absence of genes linked to antibiotic resistance, is crucial and supports its status as a promising probiotic option.

引用

页数：15