Epigenetic mechanisms in depression: Implications for pathogenesis and treatment

被引：1
|
作者：
Chen, Hong-Sheng [1 ,2 ,3 ,4 ]
Wang, Fang [1 ,2 ,3 ,4 ]
Chen, Jian-Guo [2 ,3 ,4 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pharmacol, Wuhan 430030, Peoples R China
[2] Key Lab Drug Target Res & Pharmacody nam Evaluat H, Wuhan 430030, Peoples R China
[3] Huazhong Univ Sci, Tongji Med Coll, Res Ctr Depress, Wuhan 430030, Peoples R China
[4] Minist Educ China, Key Lab Neurol Dis HUST, Wuhan 430030, Peoples R China
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2024年 / 85卷
基金：
国家重点研发计划;
关键词：
SEX-SPECIFIC ROLE; DNA METHYLATION; STRESS; SUSCEPTIBILITY; VULNERABILITY; DISORDERS; PROTEINS; PREDICTS; GENES;
D O I：
10.1016/j.conb.2024.102854
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The risk of depression is influenced by both genetic and environmental factors. It has been suggested that epigenetic mechanisms may mediate the risk of depression following exposure to adverse life events. Epigenetics encompasses stable alterations in gene expression that are controlled through transcriptional, post-transcriptional, translational, or tions, and non-coding RNA (ncRNA) regulation, without any changes in the DNA sequence. In this review, we explore recent research advancements in the realm of epigenetics concerning depression. Furthermore, we evaluate the potential of epigenetic changes as diagnostic and therapeutic biomarkers for depression.
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收藏
页数：13
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