Nanosafety: a Perspective on Nano-Bio Interactions

Engineered nanomaterials offer numerous benefits to society ranging from environmental remediation to biomedical applications such as drug or vaccine delivery as well as clean and cost-effective energy production and storage, and the promise of a more sustainable way of life. However, as nanomaterials of increasing sophistication enter the market, close attention to potential adverse effects on human health and the environment is needed. Here a critical perspective on nanotoxicological research is provided; the authors argue that it is time to leverage the knowledge regarding the biological interactions of nanomaterials to achieve a more comprehensive understanding of the human health and environmental impacts of these materials. Moreover, it is posited that nanomaterials behave like biological entities and that they should be regulated as such. This perspective addresses some of the key lessons learned in nanosafety research during the past 15 years with an emphasis on nano-bio interactions (interactions of nanomaterials with biological systems), in particular, the bio-corona and eco-corona. The authors also present a bibliometric survey of nanotoxicological research (2000-2022). image