Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer

被引：8

作者：

Zhang, Zixu ^{[1
]}

Westover, David ^{[2
]}

Tang, Zhantong ^{[1
]}

Liu, Yue ^{[1
]}

Sun, Jinghan ^{[3
]}

Sun, Yunxi ^{[1
]}

Zhang, Runqing ^{[1
]}

Wang, Xingyue ^{[1
]}

Zhou, Shihui ^{[1
]}

Hesilaiti, Nigaerayi ^{[1
]}

Xia, Qi ^{[1
]}

Du, Zhenfang ^{[1
]}

机构：

[1] Southeast Univ, Sch Med, Dept Genet & Dev Biol, Nanjing 210003, Peoples R China

[2] Merck & Co Inc, Analyt Res & Dev, High Throughput Analyt, Rahway, NJ USA

[3] Southeast Univ, Sch Life Sci & Technol, Nanjing 210018, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期

关键词：

Non-small cell lung cancer; Wnt/beta-catenin signaling; Cancer development; Therapeutic response; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR; DOWN-REGULATION; BETA-CATENIN; PATHWAY ACTIVATION; UP-REGULATION; WNT PATHWAY; PROTEIN; 8; PROMOTES; PROLIFERATION;

D O I：

10.1186/s12967-024-05380-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Wnt/beta-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote or inhibit signaling by acting on Wnt proteins, receptors, signal transducers and transcriptional effectors. The identification of these regulators and their underlying molecular mechanisms provides important implications for how to target this pathway therapeutically. In this review, we summarize recent studies of Wnt regulators in the development and therapeutic response of NSCLC.

引用

页数：26

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