SARS-CoV-2-specific mucosal immune response in vaccinated versus infected children

被引：0

作者：

Conti, Maria Giulia ^{[1
]}

Mortari, Eva Piano ^{[2
]}

Nenna, Raffaella ^{[1
]}

Pierangeli, Alessandra ^{[3
]}

Sorrentino, Leonardo ^{[3
]}

Frasca, Federica ^{[3
]}

Petrarca, Laura ^{[1
]}

Mancino, Enrica ^{[1
]}

Di Mattia, Greta ^{[1
]}

Matera, Luigi ^{[1
]}

Fracella, Matteo ^{[3
]}

Albano, Christian ^{[2
]}

Scagnolari, Carolina ^{[3
]}

Capponi, Martina ^{[1
]}

Cinicola, Bianca ^{[1
]}

Carsetti, Rita ^{[2
]}

Midulla, Fabio ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Maternal & Child Hlth & Urol Sci, Rome, Italy

[2] Ist Ricovero & Cura Carattere Sci IRCCS, B Cell Unit, Bambino Gesu Childrens Hosp, Immunol Res Area, Rome, Italy

[3] Sapienza Univ Rome, Dept Mol Med, Lab Virol, Rome, Italy

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2024年 / 14卷

关键词：

SARS-CoV-2; COVID-19; vaccines; children; immunogenicity; mucosal immunity; IGA;

D O I：

10.3389/fcimb.2024.1231697

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anti-COVID-19 intramuscular vaccination induces a strong systemic but a weak mucosal immune response in adults. Little is known about the mucosal immune response in children infected or vaccinated against SARS-CoV-2. We found that 28% of children had detectable salivary IgA against SARS-CoV-2 even before vaccination, suggesting that, in children, SARS-CoV-2 infection may be undiagnosed. After vaccination, only receptor-binding domain (RBD)-specific IgA1 significantly increased in the saliva. Conversely, infected children had significantly higher salivary RBD-IgA2 compared to IgA1, indicating that infection more than vaccination induces a specific mucosal immune response in children. Future efforts should focus on development of vaccine technologies that also activate mucosal immunity.

引用

页数：7

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