Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis

被引:0
|
作者
Jiang, Kai-Lin [1 ]
Wang, Xiang-Xiang [1 ]
Liu, Xue-Jiao [1 ]
Guo, Li-Kun [1 ]
Chen, Yong-Qi [1 ,2 ]
Jia, Qing-Ling
Yang, Ke-Ming [1 ]
Ling, Jiang-Hong [1 ]
机构
[1] Shuguang Hosp, Dept Gastroenterol, 185 Puan Rd, Shanghai 200021, Peoples R China
[2] Shuguang Hosp, Dept Pathol, Shanghai 200021, Peoples R China
基金
中国国家自然科学基金;
关键词
Gastric cancer organoids; Human-derived organoids; Gastric cancer; Cell lines; In vitro research models; RING CELL-CARCINOMA; NEUROENDOCRINE DIFFERENTIATION; INTESTINAL ORGANOIDS; STEM-CELLS; MODEL; VALIDATION; PACLITAXEL; FEATURES; DIFFUSE; BIOBANK;
D O I
10.4251/wjgo.v16.i4.1626
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND Human-derived gastric cancer organoids (GCOs) are widely used in gastric cancer research; however, the culture success rate is generally low. AIM To explore the potential influencing factors, and the literature on successful culture rates of GCOs was reviewed using meta-analysis. METHODS PubMed, Web of Science, and EMBASE were searched for studies. Two trained researchers selected the studies and extracted data. STATA 17.0 software was used for meta-analysis of the incidence of each outcome event. The adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included studies. Funnel plots and Egger's test were used to detect publication bias. Subgroup analyses were conducted for sex, tissue source, histological classification, and the pathological tumor-node-metastasis (pTNM) cancer staging system. RESULTS Eight studies with a pooled success rate of 66.6% were included. GCOs derived from women and men had success rates of 67% and 46.7%, respectively. GCOs from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9% and 53.7%, respectively. GCOs of poorly-differentiated, moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%, 31%, and 32.7%, respectively. GCOs with pTNM stages I-II and III-IV showed success rates of 38.3% and 65.2%, respectively. Y-27632 and non-Y-27632 use showed success rates of 58.2% and 70%, respectively. GCOs generated with collagenase were more successful than those constructed with Liberase TH and TrypLE (72.1% vs 71%, respectively). EDTA digestion showed a 50% lower success rate than other methods (P = 0.04). CONCLUSION GCO establishment rate is low and varies by sex, tissue source, histological type, and pTNM stage. Omitting Y-27632, and using Liberase TH, TrypLE, or collagenase yields greater success than EDTA.
引用
收藏
页码:1626 / 1646
页数:22
相关论文
共 50 条
  • [1] Influencing Factors on the Success of Mobile Learning: A Systematic Review and Meta-Analysis
    Mehrfar, Abdollah
    Zolfaghari, Zahra
    Bordbar, Arash
    Mohabbat, Zahra
    INVESTIGACION Y EDUCACION EN ENFERMERIA, 2024, 42 (03):
  • [2] Factors Influencing the Success of FMT Placed by Colonoscopy: A Systematic Review and Meta-Analysis
    Huq, Nadia
    Kumaravel, Veena
    Affi, Aboud
    Singh, Maharaj
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2017, 112 : S97 - S97
  • [3] Factors influencing occurrence of metachronous gastric cancer after endoscopic resection: a systematic review and meta-analysis
    Choe, Younghee
    Park, Jae Myung
    Kim, Joon Sung
    Cho, Yu Kyung
    Kim, Byung-Wook
    Choi, Myung-Gyu
    KOREAN JOURNAL OF INTERNAL MEDICINE, 2023, 38 (06): : 831 - +
  • [4] Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review
    Ezquerra, Sarah
    Zuleta, Amparo
    Arancibia, Rodrigo
    Estay, Jose
    Aulestia, Francisco
    Carrion, Flavio
    STEM CELLS INTERNATIONAL, 2021, 2021
  • [5] Influencing factors of lung cancer in nonsmoking women: systematic review and meta-analysis
    Huang, Jinxin
    Yue, Na
    Shi, Naiyang
    Wang, Qiang
    Cui, Tingting
    Ying, Hongyan
    Wang, Zhijian
    Leng, Jianqiang
    Sui, Zhixiang
    Xu, Yanjuan
    Wei, Bingyuan
    Jin, Hui
    JOURNAL OF PUBLIC HEALTH, 2022, 44 (02) : 259 - 268
  • [6] The Influencing Factors of Psychosocial Adaptation of Cancer Patients: A Systematic Review and Meta-Analysis
    Zhu, Hanjing
    Yang, Linning
    Yin, Hongfan
    Yuan, Xia
    Gu, Jia
    Yang, Yan
    HEALTH SERVICES INSIGHTS, 2024, 17
  • [7] Success rate of sialendoscopy. A systematic review and meta-analysis
    Beumer, L. J.
    Vissink, A.
    Gareb, B.
    Spijkervet, F. K. L.
    Delli, K.
    van Der Meij, E. H.
    ORAL DISEASES, 2024, 30 (04) : 1843 - 1860
  • [8] Incidence Rate of Gastric Cancer Adenocarcinoma in Patients With Gastric Dysplasia A Systematic Review and Meta-Analysis
    Akbari, Maryam
    Kardeh, Bahareh
    Tabrizi, Reza
    Ahmadizar, Fariba
    Lankarani, Kamran B.
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2019, 53 (10) : 703 - 710
  • [9] Gastric cancer screening: a systematic review and meta-analysis
    Faria, Lidia
    Silva, Joao Carlos
    Rodriguez-Carrasco, Marta
    Pimentel-Nunes, Pedro
    Dinis-Ribeiro, Mario
    Libanio, Diogo
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2022, 57 (10) : 1178 - 1188
  • [10] Radiotherapy for gastric cancer: a systematic review and meta-analysis
    Pang, Xiaohui
    Wei, Wanqing
    Leng, Weibing
    Chen, Qi
    Xia, Hongwei
    Chen, Liu
    Li, Ronghui
    TUMOR BIOLOGY, 2014, 35 (01) : 387 - 396