The Role of NRF2 in Cerebrovascular Protection: Implications for Vascular Cognitive Impairment and Dementia (VCID)

被引：1
|
作者：
Hu, Yizhou [1 ,2 ,3 ]
Zhang, Feng [1 ,2 ]
Ikonomovic, Milos [1 ,4 ,5 ]
Yang, Tuo [1 ,2 ,6 ]
机构：
[1] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15216 USA
[2] Univ Pittsburgh, Pittsburgh Inst Brain Disorders & Recovery, Pittsburgh, PA 15216 USA
[3] Univ Pittsburgh, Dept Internal Med, Med Ctr UPMC McKeesport, Mckeesport, PA 15132 USA
[4] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15216 USA
[5] VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15240 USA
[6] Univ Pittsburgh, Med Ctr UPMC, Dept Internal Med, Pittsburgh, PA 15216 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 07期
基金：
美国国家卫生研究院;
关键词：
aging; blood-brain barrier; oxidative stress; neuroinflammation; perivascular macrophage; lymphatic system; BLOOD-BRAIN-BARRIER; CHRONIC CEREBRAL HYPOPERFUSION; MUSCLE-CELL MIGRATION; WHITE-MATTER LESIONS; OXIDATIVE STRESS; ENDOTHELIAL-CELLS; SMOOTH-MUSCLE; NITRIC-OXIDE; ALZHEIMERS-DISEASE; PERIVASCULAR MACROPHAGES;
D O I：
10.3390/ijms25073833
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vascular cognitive impairment and dementia (VCID) represents a broad spectrum of cognitive decline secondary to cerebral vascular aging and injury. It is the second most common type of dementia, and the prevalence continues to increase. Nuclear factor erythroid 2-related factor 2 (NRF2) is enriched in the cerebral vasculature and has diverse roles in metabolic balance, mitochondrial stabilization, redox balance, and anti-inflammation. In this review, we first briefly introduce cerebrovascular aging in VCID and the NRF2 pathway. We then extensively discuss the effects of NRF2 activation in cerebrovascular components such as endothelial cells, vascular smooth muscle cells, pericytes, and perivascular macrophages. Finally, we summarize the clinical potential of NRF2 activators in VCID.
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页数：22
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