Preparation of chitosan capsule materials and its sustained release properties

被引：0
|
作者：
Liu Q. [1 ,2 ,3 ]
Xie W. [1 ]
Jia Z. [1 ,2 ,3 ]
Zhu X. [2 ]
Wang R. [2 ]
机构：
[1] College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou
[2] Zhanjiang Botai Bio-Chemical Technology Industrial Co., Ltd., Zhanjiang
[3] Guangdong Weiqian Technology Co., Ltd., Foshan
来源：
Huagong Jinzhan/Chemical Industry and Engineering Progress | 2021年 / 40卷 / 01期
关键词：
Capsule material; Carrageenan; Chitosan; Pectin; Sustained release;
D O I：
10.16085/j.issn.1000-6613.2020-0568
中图分类号：
学科分类号：
摘要：
Films material was prepared through crosslinking of chitosan and pectin. The effects of carrageenan and starch as additives on the mechanical properties of the films were investigated. The results showed that the pectin-chitosan composite membrane material without carrageenan and starch was not suitable to be used as sustained-release capsule material alone because it was insoluble in simulated gastric solution and intestinal solution. When carrageenan and starch were added, the flexibility, gelatinization, transparency and mechanical properties of the films were further improved, and the solubility of the films in simulated intestinal and gastric solution was increased. When chitosan-pectin: carrageenan: starch had a mass ratio of 2: 1: 1, the film material not only had good formability and elasticity, but also had moderate solubility in gastric solution and intestinal solution. The results of the capsule degradation showed that the capsule dissolution was a slow process in the simulated gastric solution and intestinal solution, and the sustained release rate of the capsule was about 93% after 6h immersion. © 2021, Chemical Industry Press Co., Ltd. All right reserved.
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页码：339 / 345
页数：6
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