A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19

被引:35
|
作者
Khataniar, Ankita [1 ]
Pathak, Upasana [1 ]
Rajkhowa, Sanchaita [1 ]
Jha, Anupam Nath [2 ]
机构
[1] Dibrugarh Univ, Ctr Biotechnol & Bioinformat, Dibrugarh 786004, India
[2] Tezpur Univ, Dept Mol Biol & Biotechnol, Tezpur 784028, India
来源
COVID | 2022年 / 2卷 / 02期
关键词
COVID-19; drug repurposing; repositioning; drug targets; SARS-CoV-2; MOLECULAR DOCKING; SARS-COV-2; INHIBITORS; PROTEIN; IDENTIFICATION; DYNAMICS;
D O I
10.3390/covid2020011
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Drug repurposing is a more inexpensive and shorter approach than the traditional drug discovery and development process. The concept of identifying a potent molecule from a library of pre-existing molecules or an already approved drug has become a go-to tactic to accelerate the identification of drugs that can prevent COVID-19. This seemingly uncontrollable disease is caused by SARS-CoV-2. It is a novel virus of the Betacoronavirus genus, exhibiting similarities to the previously reported SAR-CoV genome structure and viral pathogenesis. The emergence of SARS-CoV-2 and the rapid outbreak of COVID-19 have resulted in a global pandemic. Researchers are hard-pressed to develop new drugs for total containment of the disease, thus making the cost-effective drug repurposing a much more feasible approach. Therefore, the current review attempts to collate both the experimental and computational drug repurposing strategies that have been utilized against significant drug targets of SARS-CoV-2. Along with the strategies, the available druggable targets shall also be discussed. However, the occurrence of frequent recombination of the viral genome and time-bound primary analysis, resulting in insignificant data, are two major challenges that drug repurposing still faces.
引用
收藏
页码:148 / 167
页数:20
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