Recent technological advances in lab-on-a-chip for bone remodeling

被引：0

作者：

Kim, Seoyeon ^{[1
]}

Rajendran, Arun Kumar ^{[2
]}

Amirthalingam, Sivashanmugam ^{[3
]}

Kim, Jung Hun ^{[1
]}

So, Kyoung-Ha ^{[4
]}

Hwang, Nathaniel S. ^{[1
,2
,3
,4
,5
]}

机构：

[1] School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul,08826, Korea, Republic of

[2] Institute of Chemical Processes, Seoul National University, Seoul,08826, Korea, Republic of

[3] Institute of Engineering Research, Seoul National University, Seoul,08826, Korea, Republic of

[4] Bio-MAX/N-Bio, Institute of Bioengineering, Seoul National University, Seoul,08826, Korea, Republic of

[5] Interdisciplinary Program in Bioengineering, Seoul National University, Seoul,08826, Korea, Republic of

来源：

Biosensors and Bioelectronics: X | 2023年 / 14卷

基金：

新加坡国家研究基金会;

关键词：

Lab-on-a-chip (LOC) is a three-dimensional cell culture platform with a microfluidic flow that biomimics the physiological system of various organs. LOC emerged as a future replacement technology for in vitro cell-based models and in vivo animal models; gaining popularity in the field of physiology; pharmacology; and biology. Nowadays; sensors are incorporated into the LOC system to monitor real-time parameters of the cell and its microenvironment in response to biophysical and/or biochemical stimuli and maturation. A considerable amount of studies has been conducted to detect the mechanical; physical; electrical; and metabolic parameters of engineered organs. This paper aims to provide a comprehensive insight into how the biosensor-implemented LOC platform can be utilized for the analysis of tissue recapitulating systems with a focus on bone remodeling. We describe chip design; basic principles of sensors; and ongoing recent efforts to perform in-line analysis of engineered organoids. This review also presents various imaging techniques used as analytical tools for visualizing LOC. © 2023 The Author(s);

D O I：

10.1016/j.biosx.2023.100360

中图分类号：

学科分类号：

摘要：

引用

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