Association between blood groups and myocardial injury after non-cardiac surgery: a retrospective cohort study

被引:0
|
作者
Li, Jinze [1 ,2 ]
Li, Wangyu [3 ]
Li, Longyun [1 ]
Yang, Shengze [5 ]
Zhao, Guoqing [1 ,4 ]
Li, Kai [1 ]
机构
[1] Jilin Univ, China Japan Union Hosp, Dept Anesthesiol, 126th Xiantai Ave, Changchun 130033, Peoples R China
[2] Capital Med Univ, Beijing Anzhen Hosp, Dept Anesthesiol, Beijing, Peoples R China
[3] Fujian Med Univ, Fujian Prov Hosp, Dept Pain Management, Shengli Clin Med Coll, Fuzhou, Peoples R China
[4] Jilin Univ, Changchun, Peoples R China
[5] Xuzhou Med Univ, Coll Anesthesiol, Jiangsu Prov Key Lab Anesthesia & Analgesia, Xuzhou, Jiangsu, Peoples R China
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
Myocardial injury after non-cardiac surgery (MINS); Blood type; Path analysis; Cardiovascular risk; P-SELECTIN; ABO; HYPERTENSION; DIAGNOSIS; RISK;
D O I
10.1038/s41598-024-61546-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Blood group is a potential genetic element in coronary artery disease. Nevertheless, the relationship between different ABO blood groups and myocardial injury after non-cardiac surgery (MINS) is poorly understood. This study verified whether ABO blood group is a potential MINS influencing factor. This retrospective cohort study included 1201 patients who underwent elective non-cardiac surgery and a mandatory troponin test on postoperative days 1 and 2 from 2019 to 2020 at a university-affiliated tertiary hospital. The primary outcome was associations between ABO blood groups and MINS, assessed using univariate and multivariate logistic-regression analyses. Path analysis was used to investigate direct and indirect effects between blood group and MINS. MINS incidence (102/1201, 8.5%) was higher in blood-type B patients than in non-B patients [blood-type B: 44/400 (11.0%) vs. non-B: 58/801 (7.2%); adjusted odds ratio=1.57 (1.03-2.38); p=0.036]. In the confounding factor model, preoperative hypertension and coronary artery disease medical history were associated with MINS risk [adjusted odds ratio: 2.00 (1.30-3.06), p=0.002; 2.81 (1.71-4.61), p<0.001, respectively]. Path analysis did not uncover any mediating role for hypertension, diabetes, or coronary artery disease between blood type and MINS. Therefore, blood-type B is associated with higher MINS risk; potential mediators of this association need to be investigated.
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页数:7
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