EPIGENETIC NATURE OF RADIATION CARCINOGENESIS AT LOW DOSES

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T Sugahara and M WatanabeHealth Research Foundation Pasteur Building F Tanaka Monzencho Sakyoku Kyoto JapanFaculty of Pharmaceutical Sciences Nagasaki University Bunkyomachi Nagasaki Japan [5 ,103 ,5 ,606 ,1 ,14 ,852 ]
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Chinese Medical Journal | 1994年 / 06期
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<正>The present paradigm of radiation-induced carcinogenesis has been based on somatic mutation theory initiating a mutation in somatic cells derived from DNA damage by ionizing radiation. A non-threshold linear model has been assumed from high doses to low doses. As an alternative to this, we are proposing a new model that epigenetic changes induced by low dose irradiation may be a first step of carcinogenesis. Our preliminary data suggesting the epigenetic nature and reports on various stress response to ionizing radiation are presented.
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页数：6
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