Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein

被引:0
|
作者
Lu Liu [1 ]
Panpan Wang [2 ]
Aijun Liu [3 ]
Leike Zhang [4 ]
Liming Yan [1 ]
Yu Guo [5 ]
Gengfu Xiao [4 ]
Zihe Rao [1 ,5 ,6 ,7 ,8 ]
Zhiyong Lou [1 ]
机构
[1] MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University
[2] School of Life Sciences, Peking University
[3] Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong
[4] State key laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
[5] State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy, Nankai University
[6] National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
[7] Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghai Tech University
[8] Innovation Center for Pathogen Research,Guangzhou
关键词
D O I
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中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
<正>Dear Editor,The Arenaviridae family(recently assigned to the Bunyavirales order) is a group of emerging viruses that include causative agents of severe hemorrhagic fevers with high mortality in humans(de la Torre, 2009). Lymphocytic choriomeningitis virus(LCMV) is the prototypic member of the Arenaviridae family and belongs to the Old World(OW) arenavirus together with Lassa virus(LASV), which are distinct from the New World(NW) arenavirus [e.g. Machupo virus(MACV) and Junin virus(JUNV)].
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页码:703 / 725
页数:23
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