Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts

被引：0
|
作者：
YANG YanFang TANG GongWen ZHAO YunHui ZHANG Yang LI XiuLan YUAN XiaoYan School of Materials Science and EngineeringTianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin China Institute of OrthopedicsTianjin HospitalTianjin China [1 ,1 ,1 ,2 ,2 ,1 ,1 ,300072 ,2 ,300211 ]
机构：
来源：
Chinese Science Bulletin | 2011年 / 56卷 / 10期
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Osteoblasts were cultured on porous scaffolds of poly(L-lactide-co-glycolide) (PLGA) and PLGA/β-tricalcium phosphate (β-TCP) to evaluate their cytocompatibility.The proliferation of the cells on both scaffolds was examined before and after in vitro degradation for 4,8 and 12 weeks under static (shaking water bath) and dynamic (cyclic loading) conditions.Results indicate that porous PLGA and PLGA/β-TCP scaffolds have good biocompatibility and can be used as effective templates for guiding the growth of osteoblasts.The degradation of the scaffolds affects the proliferation of osteoblasts and the cell viability decreased with the degradation time.
引用
收藏
页码：982 / 986
页数：5
相关论文
共 50 条
  • [1] Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts
    Yang YanFang
    Tang GongWen
    Zhao YunHui
    Zhang Yang
    Li XiuLan
    Yuan XiaoYan
    [J]. CHINESE SCIENCE BULLETIN, 2011, 56 (10): : 982 - 986
  • [2] Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts
    YANG YanFang 1
    2 Institute of Orthopedics
    [J]. Science Bulletin, 2011, (10) : 982 - 986
  • [3] The degradation behavior of nanoscale HA/PLGA and α-TCP/PLGA composites
    Ege, Duygu
    Cameron, Ruth
    Best, Serena
    [J]. BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS, 2014, 3 (02) : 85 - 93
  • [4] MATHEMATICAL MODELLING OF PLGA-SCAFFOLDS DEGRADATION AND CELLS GROWTH ON IT
    Menshutina, Natalia
    Gordienko, Maniia
    Guseva, Elena
    Lebedev, Evgeniy
    Ivanov, Sviatoslav
    [J]. NANO, BIO AND GREEN - TECHNOLOGIES FOR A SUSTAINABLE FUTURE CONFERENCE PROCEEDINGS, SGEM 2016, VOL I, 2016, : 645 - 652
  • [5] Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds
    Lin, Liulan
    Dong, Yangyang
    Zhou, Qi
    [J]. SCIENCE AND ENGINEERING OF COMPOSITE MATERIALS, 2017, 24 (05) : 721 - 730
  • [6] Effects of β-TCP amounts on compressive strength, porosity and cytocompatibility of PLGA scaffolds
    Liang M.
    Chen H.
    Wei K.
    [J]. Gao Xiao Hua Xue Gong Cheng Xue Bao, 4 (871-877): : 871 - 877
  • [7] Effect of porogen on the physico-chemical properties and degradation performance of PLGA scaffolds
    Dorati, Rossella
    Colonna, Claudia
    Genta, Ida
    Modena, Tiziana
    Conti, Bice
    [J]. POLYMER DEGRADATION AND STABILITY, 2010, 95 (04) : 694 - 701
  • [8] Degradation behaviors of β-TCP/PLGA composites prepared with microwave energy
    Park, Hong-Chae
    Jin, Hyeong-Ho
    Hyun, Yong-Taek
    Lee, Won Ki
    Yoon, Seog-Young
    [J]. ASBM7: ADVANCED BIOMATERIALS VII, 2007, 342-343 : 205 - +
  • [9] PLGA/TCP Scaffolds Incorporating Phytoestrogenic Molecule Icaritin Dev Defect Repair
    Chen, Shihui
    Lizh
    Xie, Xinhui
    Wang, Xinluan
    Qin, Ling
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28
  • [10] Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres
    Silva, Marcela Fernandes
    Winkler Hechenleitner, Ana Adelina
    Irache, Juan Manuel
    Aparecido de Oliveira, Adilson Jesus
    Gomez Pineda, Edgardo Alfonso
    [J]. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, 2015, 18 (06): : 1400 - 1406
12345