结直肠癌的共识分子分型及其临床应用展望

被引：1
|
作者：
靳天乐 [1 ,2 ]
刘雨泉 [2 ,3 ]
王润石 [2 ]
侯妮 [3 ]
李杰 [1 ]
机构：
[1] 西安交通大学第二附属医院普通外科
[2] 西安交通大学宗濂书院
[3] 西安交通大学医学部基础医学院细胞生物学与遗传学系
来源：
西安交通大学学报(医学版) | 2024年 / 45卷 / 04期
关键词：
结直肠癌(CRC); 异质性; 共识分子分型(CMS); 临床应用;
D O I：
暂无
中图分类号：
R735.34 [];
学科分类号：
摘要：
结直肠癌(CRC)具有高度异质性。传统TNM分期不能很好地区分CRC异质性，已不能满足治疗需求。整合患者临床特征、癌组织分子遗传学变化、转录组和蛋白质组变化以及免疫基质等特征，共识分子分型(CMS)是迄今为止对CRC异质性的最佳描述。本文从三类CRC癌组织分子遗传学改变(染色体不稳定、微卫星不稳定和CpG岛甲基化表型)出发，系统阐述不同CMS分型CRC患者的临床特点、治疗方向和预后评估以及与免疫治疗和肠道微生物群组改变的联系。随着测序技术和前瞻性精准医学临床试验的持续探索，以CMS分型为基础的“多分子—多药物”治疗模式必将成为未来精准医学与个体化医疗的核心。
引用
收藏
页码：525 / 534
页数：10
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