IFN-α IL-6和IL-17检测对结核病辅助诊断价值

被引：1
|
作者：
刘战地
孙明玥
田二朋
马伟立
邸红芹
机构：
[1] 河北省胸科医院
来源：
河北医学 | 2024年 / 30卷 / 06期
关键词：
结核病; 细胞因子; IFN-α; IL-6; IL-17;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
目的:评价血清免疫细胞因子对结核分枝杆菌肺病(TB)的诊断价值。方法:回顾性选取2020年11月至2022年10月于河北省胸科医院就诊的139例疑似肺结核患者作为研究对象。按照2018年最新实施的肺结核诊断标准(WS288-2017),其中确诊结核病69例，纳入结核组，非结核病70例纳入非结核组。采用流式免疫荧光发光法检测血清中免疫相关细胞因子IL-6、IL-17和IFN-α水平，并分析三种因子检测对结核病的诊断效能。结果:结核组患者IL-6浓度和IL-17浓度显著高于非结核组，差异有统计学意义(P<0.05);结核组患者IFN-α浓度略高于非结核组，但差异无统计学意义(P>0.05);进行ROC曲线分析：IL-6检测AUC面积为0.658(P<0.001)、IL-17检测AUC面积为0.734(P<0.001)、IFN-α检测AUC面积为0.571(P<0.001)。结论:MTB感染者IL-6、IL-17水平增高，IL-6、IL-17对结核的诊断具有较好的灵敏度和特异度；IL-6、IL-17在临床辅助诊断结核病具有一定的价值。
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页码：942 / 945
页数：4
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