Multi-scale molecular dynamics simulations and applications on mechanosensitive proteins of integrins

被引：0
|
作者：
吕守芹 [1 ,2 ]
丁奇寒 [1 ,2 ]
张明焜 [1 ,2 ,3 ]
龙勉 [4 ,2 ]
机构：
[1] Center of Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory),Beijing Key Laboratory of Engineered Construction and Mechanobiology, and CAS Center for Excellence in Complex System Mechanics,Institute of Mechan
[2] Center of Biomechanics and Bioengineering, Key Laboratory of Microgravity N(ational Microgravity Laboratory),Beijing Key Laboratory of Engineered Construction and Mechanobiology, and CAS Center for Excellence in Complex System Mechanics,Institute of Mechan
[3] School of Engineering Science, University of Chinese Academy of Sciences
[4] Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology,Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences
来源：
Chinese Physics B | 2021年 / 30卷 / 03期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
Q51 [蛋白质];
学科分类号：
071010 ; 081704 ;
摘要：
Molecular dynamics simulation(MDS) is a powerful technology for investigating evolution dynamics of target proteins, and it is used widely in various fields from materials to biology. This mini-review introduced the principles, main preforming procedures, and advances of MDS, as well as its applications on the studies of conformational and allosteric dynamics of proteins especially on that of the mechanosensitive integrins. Future perspectives were also proposed. This review could provide clues in understanding the potentiality of MD simulations in structure–function relationship investigation of biological proteins.
引用
收藏
页码：11 / 18
页数：8
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