Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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作者
Glenn A.Harris [1 ]
Lauren R.Hirschfeld [1 ]
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[1] Rainwater Charitable Foundation
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R741 [神经病学];
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摘要
Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3R) or 4-repeat(4R) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.
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页码:803 / 804
页数:2
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