Advanced nano drug delivery systems for neuroprotection against ischemic stroke

被引：0

作者：

Chenchen Xie ^{[1
]}

Jun Liao ^{[1
]}

Ning Zhang ^{[2
]}

Yuhan Sun ^{[3
]}

Yi Li ^{[1
]}

Liyan Xiong ^{[1
]}

Yingnan Zhang ^{[3
]}

Xiaoyan Liu ^{[1
]}

Wei Su ^{[1
]}

Heming Chen ^{[1
]}

Ping Zeng ^{[4
]}

Xiaoqing Zhang ^{[2
]}

Ying Lu ^{[3
]}

Tingfang Wang ^{[1
]}

Chuan Zhang ^{[1
]}

机构：

[1] Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University

[2] Department of pharmacy, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University

[3] Department of Pharmaceutical Science, School of Pharmacy, Naval Medical University

[4] School of Pharmacy, Shanghai Jiao Tong University

来源：

Chinese Chemical Letters | 2024年 / 35卷 / 02期

基金：

上海市自然科学基金;

关键词：

D O I：

暂无

中图分类号：

TQ460.1 [基础理论]; TB383.1 []; R943 [制剂学];

学科分类号：

070205 ; 080501 ; 100602 ; 1007 ; 100702 ; 1406 ;

摘要：

Ischemic stroke(IS) represents a significant threat to brain health due to its elevated mortality and disability rates. The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB) and limited bioavailability. Conversely, advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations. This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS. By examining these systems, researchers and clinicians can gain valuable insights and innovative concepts, illuminating the potential of advanced neuroprotective nano drug delivery systems. Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.

引用

页码：179 / 190

页数：12

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