pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation

被引：2
|
作者：
Yan-Ling Xu [1 ,2 ]
Ao-Ting Qu [1 ]
Ru-Jiang Ma [1 ]
Ang Li [1 ]
Zhen-Kun Zhang [1 ]
Zhi-Qiang Shang [2 ]
Yao-Fang Zhang [1 ,2 ]
Lu-Xia Bu [2 ]
Ying-Li An [1 ]
机构：
[1] State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Nankai University
[2] College of Basic Science, Chemistry Experiment Teaching Center, Tianjin Agricultural University
来源：
Chinese Journal of Polymer Science | 2018年 / 36卷 / 11期
基金：
中国国家自然科学基金;
关键词：
pH-responsive; Enzymatic degradation; Poly(lactic acid);
D O I：
暂无
中图分类号：
O631 [高分子物理和高分子物理化学];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
pH-responsive micelles with a biodegradable PLA core and a mixed PEG/PDPA shell were prepared by self-assembly of poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA) and poly(2-(diisopropylamino)ethyl methacrylate)-b-poly(lactic acid) (PDPA-bPLA). The micellization status with different pH and the enzyme degradation behavior were characterized by 1 H-NMR spectroscopy,dynamic light scattering measurement and zeta potential test. The pH turning point of PDPA block was determined to be in the range of5.5-7.0. While the pH was above 7.0, the PDPA block collapsed onto the PLA core and could protect the PLA core from invasion of enzyme, as a result, the micelle exhibited a resistance to the enzymatic degradation.
引用
收藏
页码：1262 / 1268
页数：7
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