Medication Rules of Traditional Chinese Medicine for Treating Threatened Abortion in the Early Stage of Pregnancy with Subchorionic Haematoma Based on Data Mining

Objective: Using data mining technology to explore the rules of traditional Chinese medicine(TCM) in the treatment of threatened abortion in the early stage of pregnancy with sub-chorionic haematoma(SCH). Methods: Literature of TCM in the treatment of threatened abortion in the early stage of pregnancy with SCH were retrieved from CNKI, VIP, WANFANG and Pubmed, EMBASE. The literature information database was established to be used for descriptive analysis, association rule analysis and cluster analysis of relevant data. Results: A total of 100 literatures were included, involving 114 Chinese herbs. The efficacy of Chinese herbs were mainly tonic drugs, hemostatic drugs, heat-clearing drugs, dissolving blood stasis and hemostatic drugs. The medicinal properties were mostly mild and warm, and the taste of the drug was mainly sweet, bitter and pungent. The liver meridian, spleen meridian and kidney meridian were frequently used. The commonly used drug pair combination was "Xu duan(Radix dipsaci, 续断)-Tusizi(Semen Cuscutae, 菟丝子)", and the core combination was "Tusizi-Xu duan-Ejiao(Donkeyhide gelatin, 阿胶)-Baizhu(Atractylodes macrocephala, 白术)-Dangshen(Codonopsis pilosula, 党参)". Commonly used drugs for removing blood stasis and hemostasis were with Sanqi(Panax notoginseng, 三七), Puhuang(cattail pollen, 蒲黄), and Qiancao(Radix Rubiae, 茜草). Conclusion: Data mining traditional Chinese medicine for the treatment of threatened abortion in the early stage of pregnancy with SCH clinically commonly used drug efficacy, taste, meridian, commonly used drug pairs, core combination and commonly used blood stasis hemostatic drugs, has important reference significance for the treatment of threatened abortion in the early stage of pregnancy combined with SCH.