Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus

被引:0
|
作者
Longlong Tu [1 ,2 ]
Yanlin He [3 ]
Yong Xu [1 ,3 ]
机构
[1] Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine
[2] Department of Molecular and Cellular Biology,Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine
[3] Brain Glycemic and Metabolism Control Department, Pennington Biomedical Research Center, Louisiana State University
关键词
D O I
暂无
中图分类号
R338 [神经生理学];
学科分类号
0710 ; 071006 ;
摘要
Glucose is the primary fuel source of the brain,and therefore glucose levels need to be tightly regulated and maintained within a small physiological range.Certainly,the body necessitates a stable supply of energy mainly provided by glucose for various bodily functions.High or low blood glucose levels would impair the physiological functions of various organs of the body.Prolonged high blood glucose(i.e.,
引用
收藏
页码:1177 / 1178
页数:2
相关论文
共 50 条
  • [1] Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus
    Tu, Longlong
    He, Yanlin
    Xu, Yong
    [J]. NEURAL REGENERATION RESEARCH, 2024, 19 (06) : 1177 - 1178
  • [2] Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus
    Song, Zhentao
    Routh, Vanessa H.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2006, 291 (05) : R1283 - R1287
  • [3] Ventromedial hypothalamus glucose-inhibited neurones: A role in glucose and energy homeostasis?
    Hirschberg, Pamela R.
    Sarkar, Pallabi
    Teegala, Suraj B.
    Routh, Vanessa H.
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2020, 32 (01)
  • [4] Fructose Regulates the Ventromedial Hypothalamic Glucose-Inhibited Neurons
    Troy, Stephanie
    Gaspers, Lawrence D.
    Fioramonti, Xavier
    Routh, Vanessa H.
    Thomas, Andrew P.
    [J]. DIABETES, 2010, 59 : A209 - A210
  • [5] Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in glucose-inhibited neurons in the ventromedial hypothalamus
    Canabal, Debra D.
    Potian, Joseph G.
    Duran, Ricardo G.
    McArdle, Joseph J.
    Routh, Vanessa H.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 293 (02) : R592 - R600
  • [6] Anoctamin 4 channel currents activate glucose- inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia
    Tu, Longlong
    Bean, Jonathan C.
    He, Yang
    Liu, Hailan
    Yu, Meng
    Liu, Hesong
    Zhang, Nan
    Yin, Na
    Han, Junying
    Scarcelli, Nikolas A.
    Conde, Kristine M.
    Wang, Mengjie
    Li, Yongxiang
    Feng, Bing
    Gao, Peiyu
    Cai, Zhao-Lin
    Fukuda, Makoto
    Xue, Mingshan
    Tong, Qingchun
    Yang, Yongjie
    Liao, Lan
    Xu, Jianming
    Wang, Chunmei
    He, Yanlin
    Xu, Yong
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2023, 133 (14):
  • [7] Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons
    Santiago, Ammy M.
    Clegg, Deborah J.
    Routh, Vanessa H.
    [J]. MOLECULAR METABOLISM, 2016, 5 (10): : 823 - 833
  • [8] Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus
    Canabal, Debra D.
    Song, Zhentao
    Potian, Joseph G.
    Beuve, Annie
    McArdle, Joseph J.
    Routh, Vanessa H.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 292 (04) : R1418 - R1428
  • [9] Causative Role of Hypothalamic Ventromedial Glucose-Inhibited Neurons in Impaired Counterregulatory Responses to Hypoglycemia
    Copperi, Francesca
    Shen, Xiaotian
    Diano, Sabrina
    [J]. DIABETES, 2023, 72
  • [10] AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons
    Murphy, Beth Ann
    Fakira, Kurt A.
    Song, Zhentao
    Beuve, Annie
    Routh, Vanessa H.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2009, 297 (03): : C750 - C758