Animal models for the study of hepatitis B virus infection

被引：0
|
作者：
Wei-Na Guo [1 ]
Bin Zhu [1 ]
Ling Ai [1 ]
Dong-Liang Yang [1 ]
Bao-Ju Wang [1 ]
机构：
[1] Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
来源：
Zoological Research | 2018年 / 39卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Hepatitis B virus; Animal model; Duck hepatitis B virus; Woodchuck hepatitis virus;
D O I：
暂无
中图分类号：
R-332 [医用实验动物学]; R512.62 [];
学科分类号：
1001 ; 100401 ;
摘要：
Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus(HBV) worldwide. Current antiviral therapies,including interferon and nucleot(s)ide analogues,rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.
引用
收藏
页码：25 / 31
页数：7
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