SEROTONIN STIMULATES CALCIUM INFLUX IN ISOLATED RAT ADRENAL ZONA GLOMERULOSA CELLS

被引：9
|
作者：
DAVIES, E
EDWARDS, CRW
WILLIAMS, BC
机构：
[1] Department of Medicine, Western General Hospital, Edinburgh, EH4 2XU, Crewe Road
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0006-291X(91)91914-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To investigate the role of calcium as a second messenger in serotonin-stimulated aldosterone secretion, radiolabelled calcium influx studies were carried out in purified rat adrenal zona glomerulosa cells using 45CaCl2. The results show that serotonin caused calcium influx within 45 seconds of addition and this continued for up to 105 seconds. Angiotensin II also caused calcium influx; however, the effect was significantly smaller than that of serotonin. Serotonin-stimulated calcium influx could be inhibited by the calcium antagonist verapamil and by methysergide, a selective serotonin receptor type- 1 2 antagonist. The data indicate that serotonin directly stimulates calcium uptake in zona glomerulosa cells via calcium channels which are coupled to specific serotonin receptors. © 1991.
引用
收藏
页码：979 / 984
页数：6
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