PNEUMOCOCCAL CONJUGATE VACCINES

被引:23
|
作者
PEETERS, CCAM [1 ]
TENBERGENMEEKES, AM [1 ]
HAAGMANS, B [1 ]
EVENBERG, D [1 ]
POOLMAN, JT [1 ]
ZEGERS, BJM [1 ]
RIJKERS, GT [1 ]
机构
[1] NATL INST PUBL HLTH & ENVIRONM PROTECT, BACTERIAL VACCINE DEV & PATHOGENESIS RES UNIT, BILTHOVEN, NETHERLANDS
关键词
PNEUMOCOCCAL POLYSACCHARIDE; CONJUGATE VACCINE; ANTIBODY SYNTHESIS; TOLERANCE;
D O I
10.1016/0165-2478(91)90036-A
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have prepared conjugates of pneumococcal type 4 polysaccharides (PS4) or oligosaccharides to tetanus toxoid using the carbodiimide method. The use of a spacer, 6-aminohexanoic acid, resulted in higher incorporation of carrier protein. Conjugates contained up to 10% free polysaccharide, but no free protein. In general, polysaccharide conjugates induced higher anti-PS4 IgG antibody titers than oligosaccharide conjugates. Conjugates with the highest amount of incorporated protein were the most immunogenic. The response to conjugated PS4 does show characteristics of a T cell-dependent antibody response, in terms of both isotype distribution and induction of immunological memory. Repeated immunization with high doses of PS4TT conjugate resulted in a virtually negative anti-PS4 IgG response, suggestive of the induction of high dose tolerance.
引用
收藏
页码:267 / 274
页数:8
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