CLONING OF THE COCAINE-SENSITIVE BOVINE DOPAMINE TRANSPORTER

被引：211
|
作者：
USDIN, TB [1 ]
MEZEY, E [1 ]
CHEN, C [1 ]
BROWNSTEIN, MJ [1 ]
HOFFMAN, BJ [1 ]
机构：
[1] SEMMELWEIS UNIV MED,DEPT ANAT 1,H-1085 BUDAPEST 8,HUNGARY
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 24期
关键词：
NEUROTRANSMITTER UPTAKE; SUBSTANTIA NIGRA; CENTRAL NERVOUS SYSTEM;
D O I：
10.1073/pnas.88.24.11168
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A cDNA encoding the dopamine transporter from bovine brain substantia nigra was identified on the basis of its structural homology to other, recently cloned, neurotransmitter transporters. The sequence of the 693-amino acid protein is quite similar to those of the rat gamma-aminobutyric acid, human norepinephrine, and rat serotonin transporters. Dopamine transporter mRNA was detected by in situ hybridization in the substantia nigra but not in the locus coeruleus, raphe, caudate, or other brain areas. [H-3]Dopamine accumulation in tissue culture cells transfected with the cDNA was inhibited by amphetamine, cocaine, and specific inhibitors of dopamine transport, including GBR12909.
引用
收藏
页码：11168 / 11171
页数：4
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