Comparative genomic analysis of eutherian globin genes

Using eutherian comparative genomic analysis protocol and public genomic sequence assemblies, the present study attempted to update and revise eutherian globin genes implicated inmajor physiological and pathological processes. The most comprehensive curated third party data gene data set of eutherian globin genes annotated 149 complete coding sequences among 299 potential coding sequences. The present analysis first described 8 major gene clusters of eutherian globin genes, and explained their differential gene expansion patterns. The integrated gene annotations, phylogenetic analysis and protein molecular evolution analysis proposed updated classification and nomenclature of eutherian globin genes. (C) 2016 Elsevier Inc. All rights reserved.