EVOLUTION OF HUMAN ALPHA-1-ACID GLYCOPROTEIN GENES AND SURROUNDING ALU REPEATS

被引：18

作者：

MERRITT, CM ^{[1
]}

EASTEAL, S ^{[1
]}

BOARD, PG ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CLIN SCI,HUMAN GENET GRP,GPO BOX 334,CANBERRA,ACT 2601,AUSTRALIA

来源：

GENOMICS | 1990年 / 6卷 / 04期

关键词：

D O I：

10.1016/0888-7543(90)90501-K

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

There is a mosaic pattern of variation between the two tandemly arranged human α1-acid glycoprotein genes. Both the synonymous and the nonsynonymous sites of exons 3 and 4 are more divergent than the rest of the gene, suggesting that they have had a different evolutionary history. Comparisons of the two gene sequences with rat AGP indicate that exons 3 and 4 of AGP2 have been evolving without functional constraint since their divergence from AGP1. It is proposed that the conserved region of the gene has been homogenized recently by gene conversion with the homologous regions of AGP1. The Alu sequences surrounding the genes appear to have been involved in both the gene duplication and the gene conversion events. © 1990.

引用

页码：659 / 665

页数：7

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