CORRELATION BETWEEN THE INFECTIVITY OF HEPATITIS-C VIRUS IN-VIVO AND ITS INFECTIVITY IN-VITRO

被引：145
|
作者：
SHIMIZU, YK
PURCELL, RH
YOSHIKURA, H
机构：
[1] NATL INST HLTH,DEPT VIRAL DIS & VACCINE CONTROL,MUSASHIMURAYAMA,TOKYO 208,JAPAN
[2] NIH,INFECT DIS LAB,BETHESDA,MD 20892
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 13期
关键词：
D O I：
10.1073/pnas.90.13.6037
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A murine retrovirus-infected human T-cell line, HPB-Ma, supported replication of hepatitis C virus (HCV) at least as well as the previously reported Molt4-Ma cells. Cloning of HPB-Ma cells revealed a clonal variation of cellular susceptibility to HCV infection. Using one of the sensitive clones, we tested HCV inocula from different sources for their infectivity titer in cell culture. The in vitro titers obtained correlated with the reported infectivity titers of the inocula in chimpanzees. Thus, the system appears to be useful for estimating the in vivo infectivity of HCV.
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页码：6037 / 6041
页数：5
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