CORRELATION BETWEEN THE INFECTIVITY OF HEPATITIS-C VIRUS IN-VIVO AND ITS INFECTIVITY IN-VITRO

被引：145
|
作者：
SHIMIZU, YK
PURCELL, RH
YOSHIKURA, H
机构：
[1] NATL INST HLTH,DEPT VIRAL DIS & VACCINE CONTROL,MUSASHIMURAYAMA,TOKYO 208,JAPAN
[2] NIH,INFECT DIS LAB,BETHESDA,MD 20892
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 13期
关键词：
D O I：
10.1073/pnas.90.13.6037
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A murine retrovirus-infected human T-cell line, HPB-Ma, supported replication of hepatitis C virus (HCV) at least as well as the previously reported Molt4-Ma cells. Cloning of HPB-Ma cells revealed a clonal variation of cellular susceptibility to HCV infection. Using one of the sensitive clones, we tested HCV inocula from different sources for their infectivity titer in cell culture. The in vitro titers obtained correlated with the reported infectivity titers of the inocula in chimpanzees. Thus, the system appears to be useful for estimating the in vivo infectivity of HCV.
引用
收藏
页码：6037 / 6041
页数：5
相关论文
共 50 条
  • [1] SELECTIVE TRANSMISSION OF HEPATITIS-C VIRUS IN-VIVO AND IN-VITRO
    HIJIKATA, M
    MIZUNO, K
    RIKIHISA, T
    SHIMIZU, YK
    IWAMOTO, A
    NAKAJIMA, N
    YOSHIKURA, H
    ARCHIVES OF VIROLOGY, 1995, 140 (09) : 1623 - 1628
  • [2] INFECTIVITY CHANGES OF MAIZE DWARF MOSAIC VIRUS IN-VIVO AND IN-VITRO
    TU, JC
    FORD, RE
    PHYTOPATHOLOGY, 1969, 59 (12) : 1947 - &
  • [3] HEPATITIS-C VIRUS, ANTIBODIES, AND INFECTIVITY - PARADOX, PRAGMATISM, AND POLICY
    DODD, RY
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1992, 97 (01) : 4 - 6
  • [4] COMPARATIVE STUDY OF IN-VITRO INFECTIVITY AND IN-VIVO LEUKEMOGENICITY OF RAUSCHER LEUKEMIA-VIRUS VARIANTS
    BARBIERI, D
    BARSKI, G
    ANNALES DE MICROBIOLOGIE, 1973, A124 (02): : 243 - 260
  • [5] MINIMAL HEPATITIS-C INFECTIVITY IN SEMEN
    TERADA, S
    KAWANISHI, K
    KATAYAMA, K
    ANNALS OF INTERNAL MEDICINE, 1992, 117 (02) : 171 - 172
  • [6] INFECTIVITY OF BLOOD SEROPOSITIVE FOR HEPATITIS-C VIRUS-ANTIBODIES
    VANDERPOEL, CL
    REESINK, HW
    SCHAASBERG, W
    LEENTVAARKUYPERS, A
    BAKKER, E
    EXELOEHLERS, PJ
    LELIE, PN
    LANCET, 1990, 335 (8689): : 558 - 560
  • [7] Genetic Analysis of Hepatitis C Virus with Defective Genome and Its Infectivity in Vitro
    Sugiyama, Kazuo
    Suzuki, Kenji
    Nakazawa, Takahide
    Funami, Kenji
    Hishiki, Takayuki
    Ogawa, Kazuya
    Saito, Satoru
    Shimotohno, Kumiko W.
    Suzuki, Takeshi
    Shimizu, Yuko
    Tobita, Reiri
    Hijikata, Makoto
    Takaku, Hiroshi
    Shimotohno, Kunitada
    JOURNAL OF VIROLOGY, 2009, 83 (13) : 6922 - 6928
  • [8] ANTI-CRYPTOSPORIDIUM-PARVUM ANTIBODIES INHIBIT INFECTIVITY IN-VITRO AND IN-VIVO
    DOYLE, PS
    CRABB, J
    PETERSEN, C
    INFECTION AND IMMUNITY, 1993, 61 (10) : 4079 - 4084
  • [9] Correlation between in vitro and in vivo infectivity of Leishmania infantum clones
    Méndez, S
    Fernández-Pérez, FJ
    Santín, N
    De la Fuente, C
    Cuquerella, M
    Gómez-Muñoz, MT
    Alunda, JM
    JOURNAL OF EUKARYOTIC MICROBIOLOGY, 2001, 48 (06) : 616 - 621
  • [10] DYNAMICS OF HEPATITIS-C VIRUS TURNOVER IN-VIVO
    ZEUZEM, S
    SCHMIDT, JM
    LEE, JH
    RUSTER, B
    ROTH, WK
    HEPATOLOGY, 1995, 22 (04) : 723 - 723
12345