TURNING BEHAVIOR INDUCED IN MICE BY A NEUROKININ-A RECEPTOR AGONIST - STEREOSELECTIVE BLOCKADE BY SR-48968, A NONPEPTIDE RECEPTOR ANTAGONIST

被引：28
|
作者：
PONCELET, M
GUEUDET, C
EMONDSALT, X
BRELIERE, JC
LEFUR, G
SOUBRIE, P
机构：
[1] Sanofi Recherche, Montpellier
来源：
NEUROSCIENCE LETTERS | 1993年 / 149卷 / 01期
关键词：
NEUROKININ-A; NK-2; RECEPTOR; DOPAMINERGIC NEURON; STRIATUM; TURNING BEHAVIOR; MOUSE;
D O I：
10.1016/0304-3940(93)90342-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The intrastriatal injection of [Nle10]-NKA(4-10), a neurokinin A agonist, (0.05-5 ng/mouse) elicited vigorous contralateral rotations. This behavior was dose-dependently antagonized by SR 48968 (ED50: 0.15 mg/kg i.p.; 0.19 mg/kg p.o.), a selective non-peptide antagonist of NK-2 receptors, but it was not affected by spiroperidol. This suggests that NK-2 receptor stimulation may affect the activity of the striatum without necessarily involving dopaminergic systems.
引用
收藏
页码：40 / 42
页数：3
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